Fig. 7: Dynamic changes between leukemic cells of Gata2^WT/L359V-BCR/ABL and Gata2^WT/WT-BCR/ABL mice revealed by single-cell RNA-seq analysis.

A t-distributed Stochastic Neighbor Embedding (t-SNE) showing 12 clusters of BM cells from Gata2^WT/L359V-BCR/ABL and Gata2^WT/WT-BCR/ABL mice. The left panel showed the 12 clusters of the merged scRNA-seq datasets. The middle panels showed the separated illustration of the t-SNE map in Gata2^WT/L359V-BCR/ABL and Gata2^WT/WT-BCR/ABL group. The right panel showed the classification of the cell types. B Expression analysis of the cluster-specific genes. Dot plot showing the expression of representative genes across the 12 classes of cells. C t-SNE showing the expression of representative genes in different classes of cells. D Comparison of the percentage of each class of cells between Gata2^WT/L359V-BCR/ABL and Gata2^WT/WT-BCR/ABL BM.