Fig. 1: CPX inhibits proliferation and colony formation in bladder cancer cells.
From: Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting the γ-secretase complex
A Chemical structures of CPX and CPX-POM. B CPX inhibits proliferation of bladder cancer cell lines (T24, UM-UC-3, HTB-9, HTB-5, HT-1376, and RT-4). Cells were incubated with increasing concentration (0–40 μM) of CPX for up to 72 h. The treatment showed a significant dose and time-dependent decrease in cell proliferation when compared with untreated controls in the bladder cancer cell lines. C CPX inhibits colony formation. Cells were incubated with 0–20 μM CPX for 48 h and allowed to grow into colonies for 10 d. Incubation with CPX inhibits clonogenicity and number of colonies in bladder cancer cell lines (D).
