Fig. 8: Schematic model for IL-37b against endothelial cell damage in Kawasaki disease.

IL-37b binds to IL-18α and IL-1R8, inhibits ERK and NFκB activation, and finally suppresses EC apoptosis and inflammation.

IL-37b binds to IL-18α and IL-1R8, inhibits ERK and NFκB activation, and finally suppresses EC apoptosis and inflammation.