Fig. 4: KAN0441571C and venetoclax display synergy in causing SCLC cell line death.
From: Predicting ROR1/BCL2 combination targeted therapy of small cell carcinoma of the lung
A Combinatorial index (CI) values across Fa in H69 and H82 cells, where Fa is percentage cell death. Synergy is defined by CI < 1, additivity 1 <CI < 1.5, antagonism CI > 1.5. Combo2 points in H69 graph are from an additional experiment combined with the initial experiment due to initial points being clustered at high Fa values. B Isoboles at 3 Fa values in H69 and H82 cells, where Dose A is defined as KAN0441571C and Dose B is venetoclax. Synergy is defined by a combination point below the isobole, additivity a point on the isobole, and antagonism a point above the isobole.
