Fig. 2: Mutual regulation between m6A and miRNAs.
From: Interactions between m6A modification and miRNAs in malignant tumors
A In the nucleus, the intranuclear enzyme Drosha and DGCR8 cleave primary microRNA (pri-miRNA) to precursor microRNA (pre-miRNA). m6A modifications helps to recruit DGCR8 to target pri- miRNA and promote the formation of pre-miRNA. Meanwhile, HNRNPC can directly recognize the m6A sites. B In the cytoplasm, Dicer cleaves pre-miRNAs transported to the cytoplasm into mature miRNAs. C miRNAs regulate the expression of m6A regulatory proteins. miRNAs regulate the expression of mRNAs encoding for writers, erasers, and readers.
