Fig. 8: Schematic diagram of the mechanism of Prrx1 mediated malignant phenotypes in glioma. | Cell Death & Disease

Fig. 8: Schematic diagram of the mechanism of Prrx1 mediated malignant phenotypes in glioma.

From: Prrx1 promotes stemness and angiogenesis via activating TGF-β/smad pathway and upregulating proangiogenic factors in glioma

Fig. 8: Schematic diagram of the mechanism of Prrx1 mediated malignant phenotypes in glioma.

Prrx1 plays a critical role in regulating glioma stemness and angiogenesis. On the one hand, Prrx1 upregulated TGF-β1 expression by directly binding to the promoter region as a transcription factor. The autocrine TGF-β1 activates the TGF-β/smad pathway, upregulates the stemness and proangiogenic related genes, and consequently promotes stemness and angiogenesis in glioma. On the other hand, the paracrine TGF-β1 as well as other proangiogenic factors like VEGF act on the endothelial cells, promote their migration and tube formation ability and consequently stimulate the formation of glioma vessels.

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