Fig. 1: Bioinformatics analysis identified overlapped DEGs between GSE3960 and GSE54720 and performed functional enrichment. | Cell Death & Disease

Fig. 1: Bioinformatics analysis identified overlapped DEGs between GSE3960 and GSE54720 and performed functional enrichment.

From: ISL1 promoted tumorigenesis and EMT via Aurora kinase A-induced activation of PI3K/AKT signaling pathway in neuroblastoma

Fig. 1

A, B Volcano plots of GSE3960 and GSE54720, where red dots, green dots, and black dots indicate upregulated, downregulated, and not differentially expressed genes, respectively. C Venn diagram shows 22 upregulated and 28 downregulated genes. D, E Heatmaps of common DEGs between NB and normal controls in GSE3960 and GSE54720. F PPI network of overlapping DEGs at the protein level. G GO analysis reveals 50 overlapping DEGs are mostly enriched in transcription factor activity (P = 1.06 × 10−3) and regulation of transcription from RNA polymerase II promoter (P = 1.55 × 10−3). n = 50 genes, 41 Gene Ontology classification.

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