Fig. 5: ISL1-regulated NB cell invasion, migration, and apoptosis in vitro. | Cell Death & Disease

Fig. 5: ISL1-regulated NB cell invasion, migration, and apoptosis in vitro.

From: ISL1 promoted tumorigenesis and EMT via Aurora kinase A-induced activation of PI3K/AKT signaling pathway in neuroblastoma

Fig. 5

A Comparison of the invasion capacity in SK-N-SH and SK-N-BE (2) cell lines (P < 0.001). B Comparison of the migration capacity by wound healing assay in SK-N-SH and SK-N-BE (2) cell lines (P < 0.05). C, D Apoptosis analysis by flow cytometry in SK-N-SH and SK-N-BE (2) cell lines (*P < 0.05, **P < 0.01, ***P < 0.001), Q2 and Q4 regions represent the rate of early and late apoptotic cells, respectively. E, F WB analysis of apoptotic-related markers of 2 NB cell lines after knockdown of ISL1 by si-ISL1-2.

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