Fig. 6: Downregulation of ISL1 in SK-N-BE (2) cells suppressed tumorigenesis in vivo. | Cell Death & Disease

Fig. 6: Downregulation of ISL1 in SK-N-BE (2) cells suppressed tumorigenesis in vivo.

From: ISL1 promoted tumorigenesis and EMT via Aurora kinase A-induced activation of PI3K/AKT signaling pathway in neuroblastoma

Fig. 6

A Tumors from the NOD/SCID mice after subcutaneous injection with the same number of 8.0 × 106 SK-N-BE (2) cells per mouse into the inguen (n = 5 per group). All the mice were sacrificed 6 weeks later, and the primary tumor weight (P < 0.05) and volume (P < 0.01) were evaluated. B WB analysis of ISL1 in primary tumors of two groups. C IHC analysis of ISL1 in primary tumors of two groups. D, E Changes in tumor volumes and tumor weight in two groups of mice (*P < 0.05, **P < 0.01).

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