Fig. 8: Activation of PI3K/AKT pathway by ISL1 was depended on AURKA. | Cell Death & Disease

Fig. 8: Activation of PI3K/AKT pathway by ISL1 was depended on AURKA.

From: ISL1 promoted tumorigenesis and EMT via Aurora kinase A-induced activation of PI3K/AKT signaling pathway in neuroblastoma

Fig. 8

A mRNA expression level of AURKA after knockdown of ISL1 in SK-N-BE (2) and SK-N-SH cells. B CCK8 proliferation assay of ISL-overexpressed-SK-N-BE (2) and ISL-overexpressed-SK-N-SH after knockdown of AURKA with si-AURKA. C Comparison of the invasion capacity in ISL-overexpressed-SK-N-BE (2) and ISL-overexpressed-SK-N-SH after knockdown of AURKA with or without si-AURKA. D Comparison of the migration capacity in ISL-overexpressed-SK-N-BE (2) and ISL-overexpressed-SK-N-SH after knockdown of AURKA with or without si-AURKA. E, F Comparison of ISL1, AKT, p-AKT protein, and EMT-associated markers expression in ISL-overexpressed-SK-N-BE (2) and ISL-overexpressed-SK-N-SH after knockdown of AURKA with or without si-AURKA (*P < 0.05, **P < 0.01, ***P < 0.001).

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