Fig. 6: A working model of OGA-mediated deglycosylation in DNA damage repair.
From: OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair
OGA recognizes O-GlcNAcylated substrates including NONO and the Ku complex via its pseudo HAT domain at DNA damage sites. OGA deglycosylates the substrates such as NONO and facilitates the timely removal of NONO for DSB repair.
