Fig. 6: The effects of circ_0008542 in vivo. | Cell Death & Disease

Fig. 6: The effects of circ_0008542 in vivo.

From: Circ_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation

Fig. 6

Circ_0008542, MUT1956 circ_0008542, or ALKBH5 was transfected into MC3T3-E1 cells and collected from cell supernatant exosomes separately or simultaneously according to the different groups. A, C After 8 weeks of exosome injection, micro-CT, and H&E staining were applied to measure the bone histological parameters. B, D Histograms of BV/TV, BMD, Tb.Th, Tb.N, Tb.Sp, and body weight among the five groups. E TRAP staining was applied to evaluate the osteoclast differentiation and bone resorption ability. F Histograms of TRAP positive osteoclast number and integrated optical density of TRAP among the five groups. G Schematic diagram of this study. Data were representative of five independent experiments expressed as the mean ± SD. Different letters (a and b) indicate significant differences among multiple groups (p < 0.05).

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