Fig. 4: The lnc-OPHN1-5 (lnc-5) expression influences the AR mRNA translation. | Cell Death & Disease

Fig. 4: The lnc-OPHN1-5 (lnc-5) expression influences the AR mRNA translation.

From: Targeting the Lnc-OPHN1-5/androgen receptor/hnRNPA1 complex increases Enzalutamide sensitivity to better suppress prostate cancer progression

Fig. 4

A, B Knocking down lnc-5 expression (shlnc-5) increased the interaction between AR mRNA and 18S (A), while their interaction could be suppressed by ectopic lnc-5 (oelnc-5) expression in C4-2 cells by RNA immunoprecipitation (RIP) and reverse transcription-polymerase chain reaction (RT-PCR) assays (B). C Shlnc-5 expression increased the enrichment of AR mRNA in ribosome in C4-2 cells determined by RT-PCR assay. D Oelnc-5 expression decreased the enrichment of AR mRNA in ribosome in C4-2 cells determined by RT-PCR assay. *P < 0.05; **P < 0.01; ***P < 0.001; ns, no significant difference.

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