Fig. 8: Schematic model. | Cell Death & Disease

Fig. 8: Schematic model.

From: Targeting the Lnc-OPHN1-5/androgen receptor/hnRNPA1 complex increases Enzalutamide sensitivity to better suppress prostate cancer progression

Fig. 8

The lnc-OPHN1-5 (lnc-5) directly interacts with AR mRNA, reducing AR mRNA interaction with RNA binding proteins (RBPs), thus decreasing AR mRNA translation, protein expression, and transcriptional activity, enhancing Enzalutamide (Enz) treatment sensitivity. ARE, androgen receptor response element; UTR, untranslated region.

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