Fig. 4: WDR4 promotes HCC cell growth and metastasis in nude mice. | Cell Death & Disease

Fig. 4: WDR4 promotes HCC cell growth and metastasis in nude mice.

From: MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma

Fig. 4

A, B Tumour growth curves of xenograft models established from control or stable WDR4-knockdown HCC-LM3 cells. C Assessment of the weight of the dissected tumours. D WDR4 and Ki-67 expression was determined by IHC analysis. E TUNEL expression levels were determined by IF analysis. F CCNB1, CDC25C, and P21 expression were determined by IHC analysis. G Metastasis in the lungs of nude mice injected with control or stable WDR4-knockdown HCC cells. H EMT-associated protein expression was determined by IF analysis. I Images of tumour xenografts of HCC-LM3 cells under different treatments. J Curves of tumour growth in each group. K Tumour weights were measured after collection. *p < 0.05; **p < 0.01; ***p < 0.001.

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