Fig. 8: CCNB1 promotes PI3K/AKT phosphorylation and P53 ubiquitination. | Cell Death & Disease

Fig. 8: CCNB1 promotes PI3K/AKT phosphorylation and P53 ubiquitination.

From: MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma

Fig. 8

A DNA damage levels in Huh-7 cells and HCC-LM3 cells. B, C Western blot assay of cells transfected with control siRNA or CCNB1 siRNA. D, E Western blot analysis of P53 expression. F Ubiquitination assays of cells transfected with the CCNB1 expression plasmid. G Model of the regulatory mechanisms of WDR4 in HCC. *p < 0.05; **p < 0.01; ***p < 0.001.

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