Fig. 2: UPRmt activation Reduces HIMPA. | Cell Death & Disease

Fig. 2: UPRmt activation Reduces HIMPA.

From: Effect of the mitochondrial unfolded protein response on hypoxic death and mitochondrial protein aggregation

Fig. 2: UPRmt activation Reduces HIMPA.

A UPRmt-activating RNAis as assessed by hsp-6p::GFP expression. hsp-6p::GFP induction was quantified for 12 RNAis previously shown to induce the UPRmt. Fold induction of GFP fluorescence is the mean fluorescence relative to empty vector RNAi (L4440) (n = 10). Data were obtained from 10–36 individual animals for all panels; mean ± SD; **p < 0.01, ****p < 0.0001, unpaired t-test. B UCR-11:GFP HIMPA reduced by the UPRmt activating RNAis. C UPRmt activation is partially or completely blocked in the atfs-1(tm4919 lf) animals. D atfs-1(lf) reduces aggregates and suppresses a further reduction in aggregates by UPRmt-activating RNAis. E Mitochondrial translation inhibitors (doxycycline and meclocycline) reduce HIMPA in a non-additive manner along with atfs-1(lf). **p < 0.01, ***p < 0.001, ****p < 0.0001, n or ns not significant versus EV @ Bonferroni-corrected p < 0.01, unpaired t-test.

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