Fig. 3: Hepatic deletion of Depdc5 provokes ethanol-induced liver steatosis.
From: Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway
Two–three-month-old LoxP and Depdc5-LKO mice were subjected to Gao-Binge ethanol feeding. A, B Liver lysates were subjected to western blot (A) and quantification (B) analyses to examine mTORC1 signaling and AKT phosphorylation. C–E Liver-weight-to-body-weight ratios (C), serum ALT levels (D), and liver TG levels (E) were determined (n = 5–6/group). F Liver sections were analyzed through H&E and Oil Red O staining (200×). Data are presented as mean ± SD. *p < 0.05 vs PF LoxP; #p < 0.05 vs AF LoxP. Scale bars, 100 µm.
