Fig. 4: Hepatic ablation of Depdc5 aggravates ethanol-induced oxidative stress and inflammation in the liver. | Cell Death & Disease

Fig. 4: Hepatic ablation of Depdc5 aggravates ethanol-induced oxidative stress and inflammation in the liver.

From: Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway

Fig. 4

Two–three-month-old LoxP and Depdc5-LKO mice were subjected to Gao-Binge ethanol feeding. A IHC analysis of 4-HNE, F4/80, and MPO in liver sections (200×, n = 3–4/group). B Hepatic MDA measurements (n = 4–5/group). C, D Quantification of F4/80-positive cells (C) and MPO-positive cells (D) shown in (A). E qPCR analysis of hepatic mRNA expression of inflammation-related genes (n = 5/group). Data are presented as mean ± SD. *p < 0.05 vs PF LoxP; #p < 0.05 vs AF LoxP. Scale bars, 100 µm.

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