Fig. 8: A proposed model for the dysregulation DEPDC5-mTORC1 axis in the pathogenesis of alcohol-induced hepatic steatosis.
From: Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway
Chronic ethanol consumption leads to KLHL22-mediated degradation of DEPDC5, then activates mTORC1 signaling. Aberrant activation of mTORC1 reduces the expression of PPARα and its target genes, thereby resulting in alcohol-induced liver steatosis.
