Fig. 4: Knockdown of PSMC2 inhibits tumor growth of ovarian cancer in vivo. | Cell Death & Disease

Fig. 4: Knockdown of PSMC2 inhibits tumor growth of ovarian cancer in vivo.

From: PSMC2/CCND1 axis promotes development of ovarian cancer through regulating cell growth, apoptosis and migration

Fig. 4

HO-8910 cells transfected with shPSMC2 or shCtrl were used for constructing mouse xenograft models. The size of xenografts was measured and the volume of them was calculated correspondingly throughout the animal experiments (A). Before sacrificing the mice, they were subjected to in vivo imaging for observing the growth of xenograft in situ (B). After sacrificing the mice, the xenografts were removed for taking photos and weighing (C). Finally, the Histological characteristics and Ki67 levels in sections of xenografts were determined by HE and IHC staining, respectively (D). Data were presented as mean ± standard deviation (10 mice in each group). **P < 0.01, ***P < 0.001.

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