Fig. 8: Downregulation of hsa_circ_0001747 promoted autophagy induced proliferation in PCa. | Cell Death & Disease

Fig. 8: Downregulation of hsa_circ_0001747 promoted autophagy induced proliferation in PCa.

From: Autophagy-related circRNA evaluation reveals hsa_circ_0001747 as a potential favorable prognostic factor for biochemical recurrence in patients with prostate cancer

Fig. 8

A Hsa_circ_0001747 was downregulated in EBSS treatment. B Impediment of autophagy displayed no effect on the expression of hsa_circ_0001747. C Western blotting confirmed knockdown of hsa_circ_0001747 enhanced autophagy-related protein expression. D Knockdown of hsa_circ_0001747 facilitated the autophagy flux, including the autophagosomes (yellow dots) and autophagolysosomes (red dots) formation in 22Rv1 cells. E Knockdown of hsa_circ_0001747 promoted the formation of autophagosomes in 22Rv1 cells. F CQ treatment rescued the promotion of proliferation induced by knockdown of hsa_circ_0001747 in PCa. Error bar indicates mean ± SD. “ns” and “#” indicates not significant. *P < 0.05, **P < 0.01, ***P < 0.001.

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