Fig. 5: ABT-737 sensitizes for TRAIL-induced cell death in Huh7 but not Hep3B cells. | Cell Death & Disease

Fig. 5: ABT-737 sensitizes for TRAIL-induced cell death in Huh7 but not Hep3B cells.

From: BH3-only protein expression determines hepatocellular carcinoma response to sorafenib-based treatment

Fig. 5

A Detection of cell viability in Huh7 cells treated with TRAIL (50 ng/ml) or ABT-737 (5 µM) alone or in combination for 8 h. TRAIL-mediated cell death was significantly increased by combination with ABT-737 in Huh-7 cells. B Neither TRAIL alone nor its combination with the BH3-mimetic reduced cell viability in Hep3B cells. Results of five (A) or four (B) independent experiments are shown. Significances indicated above the bars refer to control. **p < 0.01; n.s. non-significant.

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