Fig. 3: STAT3 is a target of miR-526b-3p and increases in cisplatin-resistant lung cancer. | Cell Death & Disease

Fig. 3: STAT3 is a target of miR-526b-3p and increases in cisplatin-resistant lung cancer.

From: miR-526b-3p inhibits lung cancer cisplatin-resistance and metastasis by inhibiting STAT3-promoted PD-L1

Fig. 3

a The putative binding sites of STAT3 3′UTR and miR-526b-3p are shown. b The relative dual-luciferase activity of STAT3 3′UTR in the indicated cells is measured. c The representative images of STAT3 expression in lung cancer tissues are shown. Sensitive, cisplatin sensitive. Resistant, cisplatin-resistant. Scale bar, 50 µm. d The expression of STAT3 in lung cancer tissues is accessed by qRT-PCR. *, P < 0.05 vs. adjacent tissues. #, P < 0.05 vs. cisplatin-sensitive tissues. e The correlation of STAT3 and miR-526b-3p is estimated by Spearman’s correlation coefficient. *, P < 0.05.

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