Fig. 1: The research route and DEGs between AF and matched control by RRA analysis. | Cell Death & Disease

Fig. 1: The research route and DEGs between AF and matched control by RRA analysis.

From: CXCL12/CXCR4 axis as a key mediator in atrial fibrillation via bioinformatics analysis and functional identification

Fig. 1

A The research route and framework. B Heatmap shows the 35 DEGs between the AF group and matched control. There are 32 upregulated genes and three downregulated genes in AF group compared with the control group. Each row represents one gene and each column indicates one dataset. The red rectangles indicate the genes are upregulated in AF group, on the contrary, the green rectangles indicate the genes are downregulated in AF group. The number in the rectangle is the log2 FC of the gene (compare to the control group) in 5 respective datasets. C The combined log2 FC of 35 DEGs calculated by RRA based on 5 datasets. The combined log2 FC of CXCR4 and CXCL12 are 0.94 and 0.88, respectively, which means these two genes are significantly upregulated in AF group. DEG differentially expressed gene, GEO gene expression omnibus, RRA robust rank aggregation, GSE gene expression omnibus series, log2 FC log2 fold change.

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