Fig. 2: The DEGs’ GO and KEGG functional enrichment and PPI network. | Cell Death & Disease

Fig. 2: The DEGs’ GO and KEGG functional enrichment and PPI network.

From: CXCL12/CXCR4 axis as a key mediator in atrial fibrillation via bioinformatics analysis and functional identification

Fig. 2

A GO functional enrichment of DEGs, which includes BP, CC, and MF. B KEGG pathway enrichment of DEGs. GO terms and KEGG pathways are presented in the bar chart. The y-axis depicts names of GO terms and KEGG pathways, and the x-axis depicts the count of genes in each GO term or KEGG pathway. The higher q value is shown in color blue, while the lower value is shown in red. C PPI network of DEGs. The nodes represent proteins, the edges represent the interaction of proteins. The green and red diamonds indicate downregulated and upregulated DEGs in AF group respectively. The size of the diamond is positively correlated with nodes’ degree calculated by Cytohubba in the network. The larger the diamond, the higher the degree of the protein represented by the node in the network. D The top three hub genes screened by degree in PPI network. Red, greater degree. Yellow, lesser degree. GO Gene Ontology, KEGG Kyoto Encyclopedia of Genes and Genomes, DEG differentially expressed gene, BP biological process, MF molecular function, CC cellular component, PPI protein–protein interaction.

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