Fig. 3: CXCL12 and CXCR4 expression in the atria of AF patients and model mice. | Cell Death & Disease

Fig. 3: CXCL12 and CXCR4 expression in the atria of AF patients and model mice.

From: CXCL12/CXCR4 axis as a key mediator in atrial fibrillation via bioinformatics analysis and functional identification

Fig. 3

A–D The Immunohistochemistry of atrial of control and AF patients with anti-CXCL12 and CXCR4 antibody (SR, n = 7; AF, n = 10). E–F The qPCR analysis of the mRNA levels of chemokines CXCL12 and CXCR4 in the atria of control and AF model mice (n = 4). G–H The Immunohistochemistry of atrial of control and AF model mice with anti-CXCR4 antibody (n = 4). I–K AMD3100 administration prevents the induction of AF. I The representative surface electrocardiogram after the transesophageal atrial burst pacing. J Percentage of successful AF induction (n = 15). K Duration of AF in mice after AF induction (n = 15). SR Sinus rhythm, AF atrial fibrillation, Scale bar: 50 μm, Results are expressed as the mean ± SEM, and n represents the number of animals in each group. *P < 0.05, **P < 0.01, ***P < 0.001.

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