Fig. 4: AMD3100 administration prevents atrial structural remodeling. | Cell Death & Disease

Fig. 4: AMD3100 administration prevents atrial structural remodeling.

From: CXCL12/CXCR4 axis as a key mediator in atrial fibrillation via bioinformatics analysis and functional identification

Fig. 4

A–B The M-mode echocardiography of the left atrial chamber (left) and the quantification of left atrial diameter (n = 15). C–D Collagen deposition in left atrial sections detected by Masson’s trichrome staining (left). Quantification of fibrotic areas (n = 4). E–G The qPCR analysis of the mRNA levels of α-SMA, collagen -1, and collagen-3 in the atria from four groups (n = 4). H–L Immunoblotting analysis of α-SMA, collagen -1, and collagen-3 and MMP9 protein levels in the atria (upper). Quantification of each protein band (lower, n = 4). GAPDH was used as an internal control. Scale bar: 50 μm. Results are expressed as the mean ± SEM, and n represents the number of animals in each group. *P < 0.05, **P < 0.01, ***P < 0.001.

Back to article page