Table 1 Characteristics of subjects in screening and validation stages.

From: LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma

Characteristics

Gene expression sample

Dead

Alive

OS (%)

HR (95% CI)a

P valuea

(N = 100)

(N = 54)

Gender

    

0.995

Male

66 (66.00%)

41 (75.93%)

38.32%

1.00

 

Female

34 (34.00%)

13 (24.07%)

27.66%

1.00 (0.65, 1.55)

 

Age

≤60 years

32 (32.00%)

17 (31.48%)

34.69%

1.00

0.358

>60 years

68 (68.00%)

37 (68.52%)

35.24%

1.23 (0.79, 1.92)

 

T stage

    

0.046

T1–2

23 (23.00%)

22 (40.74%)

48.89%

1.00

 

T3–4

77 (77.00%)

32 (59.26%)

29.36%

1.68 (1.01, 2.80)

 

N stage

N0

46 (46.00%)

44 (81.48%)

48.89%

1.00

<0.001

N+

54 (54.00%)

10 (18.52%)

15.63%

2.44 (1.60, 3.70)

 

Differentiation

G1

32 (32.00%)

25 (46.3%)

43.86%

1.00

 

G2

61 (61.00%)

26 (48.15%)

26.89%

1.20 (0.74, 1.83)

0.429

G3

7 (7.00%)

3 (5.56%)

30%

1.33 (0.57, 311)

0.514

Location

Upper

5 (5.00%)

5 (9.26%)

50%

1.00

 

Middle

73 (73.00%)

28 (51.85%)

27.72%

1.97 (0.78, 4.99)

0.152

Lower

22 (22.00%)

21 (38.89%)

48.84%

0.78 (0.28, 2.17)

0.64

LPCAT1 (qPCR)

    

<0.001

Low expression

48 (48.00%)

49 (90.74%)

50.52%

1.00

 

High expression

52 (52.00%)

5 (9.26%)

8.77%

3.79 (2.46, 5.84)

 

LPCAT1 (IHC)

    

0.021

Low expression

63 (63%)

38 (87.04%)

37.62%

1.00

 

High expression

37 (37%)

16 (12.96%)

30.19%

1.67 (1.08, 2.59)

 
  1. aBased on Cox proportional hazards regression analysis, gender, age, TNM stage, tumor differentiation, and tumor location were adjusted when appropriate.
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