Fig. 7: OTUD6B knockdown influences ectopic pVHL and the mutants induced cell migration inhibition. | Cell Death & Disease

Fig. 7: OTUD6B knockdown influences ectopic pVHL and the mutants induced cell migration inhibition.

From: Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma

Fig. 7

a pVHL or the mutant was transfected to 786O cells with OTUD6B stable knockdown. The cell lysates were immunoblotted with indicated antibodies. b Transwell assays were conducted in 786O cells. Cell counts were shown in histogram. Results are expressed as mean ± sd. Each error bar shows the standard deviations of three independent experimental values. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, Student’s t test. c The predicted work model how OTUD6B regulated the stability of pVHL missense mutants.

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