Fig. 1: PDCD10 is upregulated in HCC tissues and is associated with poor prognosis of HCC patients. | Cell Death & Disease

Fig. 1: PDCD10 is upregulated in HCC tissues and is associated with poor prognosis of HCC patients.

From: Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation

Fig. 1

A Comparing the levels of PDCD10 mRNA in HCC tissues and normal liver tissues from Oncomine (https://www.oncomine.org/), GEO (GEO accession number: GSE57957 and GSE36376), and TCGA databases. B The mRNA and representative protein expression of PDCD10 in fresh frozen ANLTs or NLT and HCC tissues were analysed by qRT-PCR and western blotting. C The mRNA expression of PDCD10 in different HCC patient subgroups. D The mRNA and protein expression of PDCD10 in L02 and 8 HCC cell lines were analysed by qRT-PCR and western blotting, respectively. E Representative IHC images showed the protein expression of PDCD10 in ANLT, and HCC tumour tissues with or without MVI. Scale bars, 50 μm. F Kaplan–Meier analysis of overall survival and disease-free survival of HCC patients with high or low PDCD10 expression in the training cohort. G Kaplan–Meier analysis of survival probability for HCC patients based on PDCD10 mRNA expression using public data from the TCGA database. ANLT adjacent non-tumourous liver tissue, NLT normal liver tissue, T tumour tissue, MVI microvascular invasion, SHCC small hepatocellular carcinoma, SLHCC solitary large hepatocellular carcinoma, NHCC nodular hepatocellular carcinoma. n.s., no significance; *P < 0.05; **P < 0.01; ***P < 0.001.

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