Fig. 1: FGF21 treatment inhibited the apoptosis and senescence of TBHP-induced chondrocytes. | Cell Death & Disease

Fig. 1: FGF21 treatment inhibited the apoptosis and senescence of TBHP-induced chondrocytes.

From: Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway

Fig. 1: FGF21 treatment inhibited the apoptosis and senescence of TBHP-induced chondrocytes.The alternative text for this image may have been generated using AI.

A The chondrocytes were pretreated with FGF21 and subsequently with TBHP, and imaged using phase-contrast microscopy (scale bar: 20 μm). B–E Shown are protein contents of cleaved caspase3, p16INK4a, and p21WAF1 in the chondrocytes treated with TBHP and TBHP plus FGF21. F–H TUNEL assay and SA-β-gal staining assay were performed in the chondrocytes as treated above (scale bar: 50 μm). The data in the figures are the averages ± S.D. Significant differences between the treatment and control groups are indicated as **P < 0.01 and *P < 0.05, n = 3.

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