Fig. 2: FGF21 treatment inhibited the TBHP-induced catabolism of the ECM. | Cell Death & Disease

Fig. 2: FGF21 treatment inhibited the TBHP-induced catabolism of the ECM.

From: Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway

Fig. 2: FGF21 treatment inhibited the TBHP-induced catabolism of the ECM.The alternative text for this image may have been generated using AI.

A, B Shown is the change in the levels of Aggrecan, Collagen II, ADAMTS5, and MMP13 in the chondrocytes, evaluated by the western blot analysis. C–F Shown is the mRNA expression of Aggrecan, Collagen II, ADAMTS5, and MMP13 in the chondrocytes treated with TBHP and TBHP plus FGF21, measured using real-time PCR. The data in the figures are the averages ± S.D. Significant differences between the treatment and control groups are indicated as **P < 0.01 and *P < 0.05, n = 3.

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