Fig. 4: CQ reversed the effect of FGF21 on the apoptosis and senescence of chondrocytes under oxidative stress. | Cell Death & Disease

Fig. 4: CQ reversed the effect of FGF21 on the apoptosis and senescence of chondrocytes under oxidative stress.

From: Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway

Fig. 4: CQ reversed the effect of FGF21 on the apoptosis and senescence of chondrocytes under oxidative stress.The alternative text for this image may have been generated using AI.

A, B Shown is the protein expression of C-caspase3, Bax, Bcl-2, p16INK4a, and p21WAF1 in the chondrocytes treated as above. C, D The immunofluorescence analysis of C-caspase3 proteins in the chondrocytes as treated above (scale bar: 20 μm). E, F The SA-β-gal staining assay was performed in the chondrocytes as treated above (scale bar: 50 μm). The data in the figures are the averages ± S.D. Significant differences between the treatment and control groups are indicated as **P < 0.01 and *P < 0.05, n = 3.

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