Fig. 5: CQ reversed the effect of FGF21 on the ECM of chondrocytes under oxidative stress. | Cell Death & Disease

Fig. 5: CQ reversed the effect of FGF21 on the ECM of chondrocytes under oxidative stress.

From: Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway

Fig. 5: CQ reversed the effect of FGF21 on the ECM of chondrocytes under oxidative stress.The alternative text for this image may have been generated using AI.

A, B Shown are the changes in the levels of Collagen II and MMP13 in chondrocytes, evaluated using western blot analysis. C, D The representative Collagen II was detected using the immunofluorescence analysis combined with DAPI staining for the nuclei (scale bar of Collagen II: 20 μm; scale bar of MMP13: 20 μm). The data in the figures are the averages ± S.D. Significant differences between the treatment and control groups are indicated as **P < 0.01 and *P < 0.05, n = 3.

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