Fig. 6: FGF21 upregulated autophagy flux by enhancing the TFEB activity. | Cell Death & Disease

Fig. 6: FGF21 upregulated autophagy flux by enhancing the TFEB activity.

From: Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway

Fig. 6: FGF21 upregulated autophagy flux by enhancing the TFEB activity.The alternative text for this image may have been generated using AI.

A–C Western blotting revealed the levels of cytoplasmic TFEB and nuclear TFEB in chondrocytes as treated above. D, E Western blotting revealed the levels of the autophagic proteins (p62 and LC3II) and Lysosomal protein (Lamp1) in chondrocytes as treated above. F, G The mRFP-GFP-LC3 assay was performed to detect the number of autophagosomes in chondrocytes (yellow signal represents autophagosomes; red signal represents autophagolysosomes; scale bar: 10 μm). The data in the figures are the averages ± S.D. Significant differences between the treatment and control groups are indicated as **P < 0.01 and *P < 0.05, n = 3.

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