Fig. 7: FGF21 activated the SIRT1-mTOR pathway in the chondrocytes induced by TBHP. | Cell Death & Disease

Fig. 7: FGF21 activated the SIRT1-mTOR pathway in the chondrocytes induced by TBHP.

From: Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway

Fig. 7: FGF21 activated the SIRT1-mTOR pathway in the chondrocytes induced by TBHP.The alternative text for this image may have been generated using AI.

A, E Western blotting revealed the levels of SIRT1, mTOR, p-mTOR, cytoplasmic TFEB, and nuclear TFEB in chondrocytes as treated above. B–D Shown is the protein expression of Collagen II, MMP13, C-caspase3, and p16INK4a in the chondrocytes as treated above. F, G TUNEL assay was performed in the chondrocytes as treated above (scale bar: 50 μm). H, I The representative MMP13 was detected using the immunofluorescence analysis combined with DAPI staining for the nuclei in the chondrocytes as treated above (scale bar for MMP13: 20 μm). Significant differences between the treatment and control groups are indicated as **P < 0.01 and *P < 0.05, n = 3.

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