Fig. 8: FGF21 inhibited OA progression in the DMM mouse model via the SIRT1-mTOR signaling pathway. | Cell Death & Disease

Fig. 8: FGF21 inhibited OA progression in the DMM mouse model via the SIRT1-mTOR signaling pathway.

From: Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway

Fig. 8: FGF21 inhibited OA progression in the DMM mouse model via the SIRT1-mTOR signaling pathway.The alternative text for this image may have been generated using AI.

A Shown are the digital X-ray images of the mouse knee joints from different groups. B Shown are the representative H&E, S-O, and Alcian Blue staining of cartilage in each group, 8 weeks after the surgery (scale bar: 200 μm). C Shown are the OARIS scores for the cartilages in each group. D–H Shown are the expressions of LC3, Lamp1, p16INK4a, and MMP13, evaluated using immunohistochemistry staining (scale bar: 20 μm). Significant differences between the treatment and control groups are indicated as **P < 0.01 and *P < 0.05, n = 6.

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