Fig. 3: Anti-TNFSF10 treatment decreased miR-155 retinal levels in 15-month-old 3xTg-AD mice. | Cell Death & Disease

Fig. 3: Anti-TNFSF10 treatment decreased miR-155 retinal levels in 15-month-old 3xTg-AD mice.

From: Targeting the miRNA-155/TNFSF10 network restrains inflammatory response in the retina in a mouse model of Alzheimer’s disease

Fig. 3

A RT-qPCR was performed to determine the retinal expression of miR-155-5p in 15-month-old 3xTg-AD mice treated with anti-TNFSF10. One-way ANOVA and post-hoc Tukey’s multiple comparisons test were used. N = 5 animals; 5 independent retinal samples, 2 pooled retinas per sample in each group. B Bioinformatic prediction of SOCS-1 mRNA binding with miR-155-5p. C Western blot analysis was performed to evaluate the expression of the miR-155-5p molecular target SOCS-1 in the retinas of 3xTg-AD mice. D Densitometric analysis of western blots. Data are expressed as mean ± standard deviation. One-way ANOVA and post-hoc Tukey’s multiple comparisons test were used to determine statistical significance. *p < 0.05. N = 5 animals; 5 independent retinal samples, 2 pooled retinas per sample in each group.

Back to article page