Fig. 1: PPP6C is essential for male fertility. | Cell Death & Disease

Fig. 1: PPP6C is essential for male fertility.

From: Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis

Fig. 1

A Schematic diagram of deletion of Ppp6c exons and creation of Ppp6c Δ allele by AMH-Cre-mediated recombination in Sertoli cells. B Western blotting analysis of PPP6C protein in Ppp6cWT and Ppp6ccKO Sertoli cells of 8-week-old mice. α-tubulin was detected as an internal control. C Pregnancy rates (%) of plugged wild-type females after mating with Ppp6ccKO or Ppp6cWT 8-week-old males. D Average litter size of plugged wild-type females after mating with Ppp6ccKO or Ppp6cWT 8-week-old males. For this part, at least 3 mice (8-week-old) of each genotype were used for analysis. Data are presented as the mean ± SEM. P < 0.05(*), 0.01(**), or 0.001(***).

Back to article page