Fig. 1: UCP2 downregulation reduces autophagy whereas UCP2 overexpression is associated with increased autophagy. | Cell Death & Disease

Fig. 1: UCP2 downregulation reduces autophagy whereas UCP2 overexpression is associated with increased autophagy.

From: An interplay between UCP2 and ROS protects cells from high-salt-induced injury through autophagy stimulation

Fig. 1

Level of autophagy in UCP2-silenced microvascular endothelial cells (siUCP2) (A) or cells overexpressing UCP2 (ovUCP2) for 24 h (N = 5) (B). Level of autophagy in renal proximal tubular epithelial cells silenced for UCP2 (siUCP2) (C) or overexpressing UCP2 (ovUCP2) for 24 h (D) (N = 7). CTR indicates not transfected cells. Representative western blots of LC3-I/II and ATG7 and corresponding quantification are reported. *p < 0.05, **p < 0.001 obtained using the two-tailed students t-test. Data are reported as mean ± SEM.

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