Fig. 7: Graphic illustration of the synthetic lethal interaction between mitotic kinase inhibition and OXPHOS inhibition. | Cell Death & Disease

Fig. 7: Graphic illustration of the synthetic lethal interaction between mitotic kinase inhibition and OXPHOS inhibition.

From: Modulation of oxidative phosphorylation augments antineoplastic activity of mitotic aurora kinase inhibition

Fig. 7

Upper panel: Genome-wide knockout screening and KEGG pathway mapping of synthetic lethal targets of alisertib. Lower panel: Alisertib treatment reduces ATP concentrations in mitotic cells and OXPHOS inhibitors enhance the antineoplastic activity of alisertib through joint strike on energy homeostasis in mitotic cells. OXPHOS inhibitor treatment further reduces the intracellular ATP concentration in alisertib-treated mitotic cells, increasing the frequency of death in mitosis and cytokinesis failure.

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