Fig. 7: Hsa_circ_0043280 inhibited the proliferation and metastasis of CCa via the miR-203a-3p/PAQR3 axis. | Cell Death & Disease

Fig. 7: Hsa_circ_0043280 inhibited the proliferation and metastasis of CCa via the miR-203a-3p/PAQR3 axis.

From: Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis

Fig. 7: Hsa_circ_0043280 inhibited the proliferation and metastasis of CCa via the miR-203a-3p/PAQR3 axis.

A The proliferative abilities of MS751 and HeLa cells were detected by EdU assays in the indicated cells. Original magnification, × 100. B, C Transwell assays were performed to investigate the migration and invasion abilities of MS751 and HeLa cell lines in the indicated groups. Original magnification, × 100. D Western blot analysis of the protein levels of various EMT markers Snail, E-cadherin, N-cadherin and Vimentin, p-ERK, and p-AKT in the indicated cells. E Schematic illustrating the hsa_circ_0043280/miR-203a-3p/PAQR3 signaling pathways in CCa. Hsa_circ_0043280 regulates the expression of PAQR3 by sponging miR-203a-3p and repressing the tumor growth and metastasis of CCa. Each experiment was performed at least three times independently. **P < 0.01; ***P < 0.001.

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