Fig. 4: The neuroinflammation was aggravated and the proliferation of astrocytes was reduced in the spinal cords of YAPGFAP-CKO EAE mice. | Cell Death & Disease

Fig. 4: The neuroinflammation was aggravated and the proliferation of astrocytes was reduced in the spinal cords of YAPGFAP-CKO EAE mice.

From: Astrocytic YAP prevents the demyelination through promoting expression of cholesterol synthesis genes in experimental autoimmune encephalomyelitis

Fig. 4: The neuroinflammation was aggravated and the proliferation of astrocytes was reduced in the spinal cords of YAPGFAP-CKO EAE mice.

A, B Immunostaining of Iba1 (green) and GFAP (red) (A), and PH3 (green) and GFAP (red) (B) in the lumbar spinal cords of YAPf/f and YAPGFAP-CKO EAE mice. C, D Quantification of the density of Iba1+ (C) and GFAP+ (D) cells in shown in A (n = 6). E Quantification of the percentage of PH3+ and GFAP+ cells over total GFAP+ cells in one field as shown in B (n = 6). Scale bars, 50 μm. Data were mean ± SEM. Student’s t-test, **p < 0.01, ***p < 0.001.

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