Fig. 8: A working model of astrocytic YAP’s function in EAE mice. | Cell Death & Disease

Fig. 8: A working model of astrocytic YAP’s function in EAE mice.

From: Astrocytic YAP prevents the demyelination through promoting expression of cholesterol synthesis genes in experimental autoimmune encephalomyelitis

Fig. 8: A working model of astrocytic YAP’s function in EAE mice.

In the spinal cords of EAE mice, YAP is upregulated and activated in astrocytes by suppression of Hippo signaling including MST1/2, SAV1, LATS1/2 and MOB1, and promotes the proliferation of astrocytes and induces the expression of cholesterol-synthesis genes such as HMGCS1, which prevents the neuroinflammation and demyelination. XMU-MP-1, an inhibitor of MST1/2; DPN, an ERβ-ligand.

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