Fig. 5: Pathway differences between CSF and primary lesions. | Cell Death & Disease

Fig. 5: Pathway differences between CSF and primary lesions.

From: Genomic comparison between cerebrospinal fluid and primary tumor revealed the genetic events associated with brain metastasis in lung adenocarcinoma

Fig. 5: Pathway differences between CSF and primary lesions.

A Remarkable enrichment of KEGG pathways in each group according to FDR < 0.1. The vertical axis indicates gene count. Gene count means the number of mutated genes enriched in one term. B Heatmap of alteration frequency of identified pathways. The horizontal axis represents signal pathways, and the figures indicate mutation percentages. Differences with significant P values are labeled (two-sided Fisher’s exact test). **P < 0.01, ***P < 0.001. C Gene alterations (including SNV and CNV) of highly frequent and unique pathways in CSF samples. The vertical axis shows gene mutation frequency.

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