Fig. 7: Clonal and subclonal mutations in CSF and primary lung tumors. | Cell Death & Disease

Fig. 7: Clonal and subclonal mutations in CSF and primary lung tumors.

From: Genomic comparison between cerebrospinal fluid and primary tumor revealed the genetic events associated with brain metastasis in lung adenocarcinoma

Fig. 7: Clonal and subclonal mutations in CSF and primary lung tumors.

A–C Comparison of total clonal mutations burden (including clonal and subclonal), clonal mutation burden, and subclonal mutation burden in all somatic genes for CSF and the other three groups. Clonal mutations burden means the number of mutation clusters in each sample. Differences with significant P values are labeled (Mann–Whitney test). **P < 0.01, ***P < 0.001. D The clonal and subclonal proportion of EGFR and EGFR genotyping (L858R, T790M, and 19del) in CSF and primary lung tissue. The differences of these clonal distribution were estimated by two-sided Fisher’s exact test. *P < 0.05, **P < 0.01, ***P < 0.001.

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