Fig. 2: Sitagliptin downregulated autophagy level in SAP-ALI. | Cell Death & Disease

Fig. 2: Sitagliptin downregulated autophagy level in SAP-ALI.

From: Sitagliptin activates the p62–Keap1–Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury

Fig. 2: Sitagliptin downregulated autophagy level in SAP-ALI.

A Immunofluorescence staining for LC3-II in the lung (×200). B The representative TEM photo of the lung tissue. Red arrows: autophagic vacuoles (AVs). C, D Western blotting results and analysis of Beclin1, Atg5, and LC3-ll in different groups. Beclin1 and Atg5 versus β-actin, LC3-II versus LC3-I. **P < 0.05. Data are presented as mean ± standard error of the mean (SEM) (n = 6).

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