Fig. 6: Dihydroartemisinin reduces Ki-67 expression and induces apoptosis in CRC, both in vitro and in vivo. | Cell Death & Disease

Fig. 6: Dihydroartemisinin reduces Ki-67 expression and induces apoptosis in CRC, both in vitro and in vivo.

From: Dihydroartemisinin is potential therapeutics for treating late-stage CRC by targeting the elevated c-Myc level

Fig. 6

Immunohistochemistry staining showing the expressions of Ki67 in the tumors of the (A) xenograft mouse models and (B) orthotopic mouse models after dihydroartemisinin (DHA) treatments at the indicated doses. C, D Percentages of apoptotic cells after dihydroartemisinin (DHA) treatments at the indicated concentrations. The data are shown as means ± SEM. n = 3 independent experiments, *p < 0.05, **p < 0.01 compared with control. E Western blot showing the expressions of cleaved caspase-3, Bcl-2, Bax, and cleaved PARP in the CRC cells after dihydroartemisinin (DHA) treatments at the indicated concentrations. F Western blot showing the expressions of cleaved caspase-3 and cleaved PARP in the xenograft tissues of the DLD-1-bearing xenograft mouse models after dihydroartemisinin (DHA) treatment at the indicated doses.

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