Fig. 1: Scheme of KNL1, ASPM, CENPE, CITK, and KIF14 localization during mitosis.
From: Inhibiting microcephaly genes as alternative to microtubule targeting agents to treat brain tumors
During metaphase, KNL1 and CENPE are localized to kinetochore, where they promote microtubule-kinetochore attachment and correct chromosome alignment. KNL1 and CENPE remain localized to kinetochore up to anaphase. During metaphase-anaphase transition, ASPM, CITK, and KIF14 are found at spindle poles and their associated microtubules. ASPM and CITK are able to interact with astral microtubules and promote their growth. In the transition to telophase, CENPE ASPM, CITK, and KIF14 translocate to the central spindle and then localize at the midbody.
